Focus area Inflammation II

Module code

mlsInflammationII-01a

Abbreviated title

Inflammation II

Module components

Lab seminar, lab practical, joint seminar of all focus areas

When

Semester 3

Module coordinator/

Organiser

R. Häsler

Dermatology

Lecturers

Principal investigators of research groups working on research topics of focus areas (joint seminars)

Contact hours

Practical 9 CH            Lab seminar 1 CH                Joint seminar 1 CH

Workload

Total:  330 h

Lab practical: 240 h
Attendance time 100 h, preparation 60 h, revision 80 h

Lab seminar: 60 h

Attendance time 14 h, preparation 26 h, revision 20 h
Joint seminar “Current affairs”:
Attendance time 14 h, preparation 10 h, revision 6 h

Credit points

11 (practical 8 CP, seminar 2 CP, joint seminar 1 CP)

Requirements

Inflammation I passed

Expected outcome

Knowledge: Students

- have an in-depth understanding of physiological and molecular/cell biological processes which influence inflammatory diseases

- can comprehend literature describing lab techniques in inflammation research and explain essential methods such as immunoelectrophoresis, lymphocyte transformation

- have in-depth knowledge of the experiments conducted during the practical.

Skills: Students

- can conduct the different steps of their lab experiments self-reliantly, document them correctly in lab books and explain them

- are able to perform quality control measures for the results obtained

- can analyse the results and put them into relation to the research area.

Competences: Students

- can plan experiments self-reliantly, can analyse the data obtained and interpret results using the knowledge they have acquired

- can assess their own work critically and integrate new results adequately

- can familiarize themselves with new topics and develop relevant research lab research approaches

- recognize the connections between topics of different focus areas and can explain and link them correctly

- are aware of the connections between the topics of the different focus areas and can elucidate them.

Content

Seminar: Developing a lab project by researching literature and discussions with fellow students and lecturers for topics such as T-cell, B-cell mediated immune reactions, auto-antigens, autoantibody formation, pro-inflammatory cytokines, signal transduction pathways for activating cell migration and pathogen destruction.

Practical: Preparation and execution of experimental lab project making use of methods such as ELISA, RIA, ELISPOT, allergen tests, infection/stimulation experiments with primary macrophages, transformation/transfection of model organisms, FACS analysis of Toll-like receptor expression.

Joint seminar: Joint discussion of papers relevant for all focus areas.

Module evaluation/

exam

Graded

Scientific project thesis with oral presentation

Media used

PPT presentations, lab/lecture notes, lab manuals and instructions, lab experiments.

Literature

Cavaillon J-M, Singer M, Inflammation: From Molecular and Cellular Mechanisms to the Clinic (Wiley 2017)

Bondy, S C; Campbell A, Inflammation, Aging, and Oxidative Stress (Humana Press 2016)

Miyasaka M, Takatsu K, Chronic Inflammation – Mechanisms and Regulation (Springer 2016)

Current original publications and reviews