Clinical manifestations of diseases and cell biology for clinical research

Module code

mlsIntroMed-01a

Abbreviated title

IntroMed

Module components

Lectures, diagnostics lab tutorial, seminar

When

Semester 1

Module coordinator

Organiser

E. Hütten

A. Klettner (Ophthalmology) + H. Emmert (Dermatology); K. Reiß (Dermatology)

Lecturers

Clinical manifestations of diseases:  A. Klettner (Ophthalmology), K. Aden (Med. Department I), H. Emmert, A. Remes (Cardiology)

Clinical Cell Biology: K. Reiß (Dermatology), H. Schäfer (IET), S. Fuchs (Trauma Surgery), J. Harder (Dermatology), C. Geismann (Med. Department I), A. Klettner (Ophthalmology)

Contact hours

Lecture Clinical manifestations 2 CH           Diagnostics lab tutorial 1 CH
Lecture Clinical cell biology 2 CH                  Seminar Clinical cell biology 1 CH

Workload

Total: 180 h

Lecture Clinical manifestations of diseases: 60 h
Attendance time 26 h, preparation 10 h, revision 24 h
Tutorial Clinical manifestations of diseases: 30 h
Attendance time 14 h, preparation 6 h, revision 10 h
Lecture Clinical cell biology: 60 h
Attendance time 26 h, preparation 10 h, revision 24 h

Seminar Clinical cell biology: 30 h
Attendance time 14 h, preparation 10 h, revision 6 h

Credit points

6 (lecture Clinical manifestations 2 CP, tutorial 1 CP; lecture Clinical cell Biology 2 CP, seminar 1 CP)

Requirements

-

Expected outcome

Knowledge: Students

- can apply and explain the most important medical terms correctly
- have an overview knowledge of factors and clinical manifestations of non-contagious diseases (including civilization diseases) and epidemiologically significant infectious diseases of temperate latitudes

- are familiar with the basics of molecular and cell biological processes and their relevance for disease-related alterations

- understand the pathomechanisms of chronic inflammatory and degenerative diseases,

- have an overview of model systems for basic and translational research.

Skills: Students

-have acquired skills in applying basic techniques in dedicated research labs in cardiology, ophthalmology and dermatology, e.g. cell isolation, microscope techniques to detect aberrations in tissue thin sections, staining cells, live cell imaging techniques, assessment of mitochondria function in hypoxic conditions.

Competences: Students

- understand the significance of clinical aspects of their studies and are aware of the interaction between and interdependence of research and treatment of diseases
- understand molecular and cell biological processes in disease development conceptually

-can transfer the acquired conceptual knowledge.

Content

Lecture Clinical manifestations of diseases: Typical disease manifestations and epidemiology of non-infectious diseases (including civilization diseases), basic medical terminology, theoretical introduction to clinical problems (e.g. allergies, physiology of the skin, skin diseases, cardiovascular system, anatomy and physiology of the eye and ophthalmological diseases). Introduction to cellular and molecular processes in disease development and progression, introduction into experimental model systems, introduction to molecular research in non-contagious diseases, understanding of molecular mechanisms behind pharmacological treatments for cardiovascular disease. Basics behind various in vitro and in vivo modeling strategies for cardiovascular disease and importance of bench to bedside transfer of knowledge.

Diagnostics lab tutorial: Laboratory aspects of molecular research in ophthalmology, cardiology and dermatology for degenerative and chronic inflammatory diseases, practical exercises.

Lecture Clinical cell biology: Carbohydrate/Lipid  and energy metabolism, liver metabolism, cell communication, basics of signal transduction, regulation/ deregulation of ligand-receptor interactions, Ubiqitin-Proteasome System, oxidative and genotoxic stress, proteolysis as regulative mechanism in cell biology and pathophysiology: classes of proteases, ectodomain proteolysis, intra-membrane proteolysis, regulation of signal transduction by proteolysis; transcription factor NFκB, phospholiophase A2 family, signal transduction in antigen presentation and co-stimulation, compartmentalisation of signalling pathways, cytoskeleton and motor proteins, cell organelles function and associated diseases.

Seminar Clinical cell biology: Knowledge consolidation via current publications

Module evaluation/

exam

Graded

Clinical cell biology: oral exam [individual exam]
Clinical manifestations of diseases: written exam [individual exam]

Weight of each exam part for final grade: 50%

Media used

PPT presentations, clinical case studies, handouts, textbooks.

Literature

Clinical manifestations of diseases

Current scientific publications

Clinical cell biology

Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P, Molecular Biology of the Cell (Garland Science 6^th edition 2014)

Deans K, Murphy M, Srivastava R, Clinical biochemistry – an illustrated colour text (Elsevier 6^th edition, 2018)

Nelson DL, Cox MM, Lehninger - Principles of Biochemistry: International Edition (Macmillan Education 8^th edition, 2021)

Current scientific publications