Pathology and Immunology

Module code

mlsMolPathoImmu-01a

Abbreviated title

MolPatho/Immu

Module components

Lectures, seminar

When

Semesters 1+2 (duration of each part: 2 semesters)

Module coordinator/

Organisers

 E. Hütten

Lecturers

Pathology: P. Rosenstiel (IKMB) 

Immunology: D. Wesch, H. Oberg, D. Adam, O. Janssen, M. Lettau, A. Scheffold (Immunology)

Contact hours

Lecture Pathology 3 CH                 Lecture Mol. Pathology 1 CH                                Seminar Pathology 1 CH                Lecture Basic immunology 2 CH     

Lecture Molecular immunology 2 CH

[Immunology also for Biochemistry + Molecular Biology/Biology MSc students]

Workload

Total: 240 h

Lecture Pathology 1st semester: 90 h
Attendance time 38 h, preparation 20 h, revision 32 h
Lecture Molecular Pathology 2nd semester: 30 h
Attendance time 14 h, preparation 6 h, revision 10 h
Seminar Molecular pathology 2nd semester: 60 h
Attendance time 14 h, preparation 24 h, revision 22 h

Lecture Introduction to immunology 1st semester: 30 h

Attendance time 26 h, revision 4 h

Lecture Introduction to molecular immunology 2nd semester: 30 h

Attendance time 26 h, revision 4 h

Credit points

8 (lecture Pathology 3 CP; lecture Mol. Pathology 1 CP, seminar 2 CP; lecture Immunology 1 CP, lecture Mol. immunology 1 CP)

Requirements

-

Expected outcome

Knowledge: Students

- understand pathological processes of primary disease entities
- understand neoplastic and inflammatory processes and their impact on tissue
- understand the principles of molecular and cellular change in degenerative diseases of different organ systems (e.g. Alzheimer’s disease, Parkinson’s disease, prion diseases of the CNS)

- are familiar with the development, roles and interaction of cellular and humoral components of innate and adaptive immunity

- have a good understanding of the molecular basics of the development of the immune system demonstrated at model systems of various species
- are familiar with the molecular basics to differentiate between leucocyte populations (surface antigens, flow cytometry)

- have gained thorough knowledge about the molecular interactions of antigen receptor-induced activation and cytokine-induced activation, differentiation and effector function of various leucocytes populations

- understand the molecular context of selected key signal transduction pathways in cell growth and cell death

- understand normal and pathological immune responses for e.g. allergies, autoimmune diseases, infections, congenital/ acquired immune deficiencies, tumour development, prion diseases, graft rejections.

Skills: Students

- recognise macro- and microscopic pathological changes and can link them to molecular processes

- recognise, understand and can explain cellular processes such as cell differen-tiation, cell division and cell death for chosen examples.

Competences: Students

- understand pathology of malign processes as a concept and can transfer their knowledge to other topics within their studies.

Content

Lectures and seminar Pathology, Molecular pathology: Organisation of the cell/ cell layers/organs; injury and cell death; cell organelles and specific diseases (storage diseases, mitochondrial diseases); regeneration and proliferation; basics of neoplastic diseases; inflammation and diseases of the immune system; bacterial infectious diseases, sepsis, viral infectious diseases; haemorrhage and ischaemia; senescence and age-related changes in cells; degenerative processes;  diagnostic techniques; animal models in researching human diseases.

Lecture Basic immunology: Basics of immunology, evolution of the immune system; innate and adaptive immunity; antigen presentation and dendritic cells; T-cell and their subpopulations; B-cells and antibodies; allergy, autoimmunity, immunology of infection, tumour immunology, immune deficiencies, tolerance and transplantation immunology, immunology of the skin, immunodiagnostics, tissue typing.

Lecture Molecular immunology: Receptor evolution in the innate/adaptive immune system; animal models in immunology; specificity of the immune system: T-cell and B-cell receptors; immune response regulation by cytokines and growth factors; cell growth and apoptosis; compartmentalisation of pathways; techniques in cellular and molecular immunology.

Module evaluation/

exam

Graded

Oral exam in Pathology (2^nd semester); no exam in Immunology

Media used

PPT presentations, handouts

Literature

Pathology

Kumar V, Abbas AK, Aster J, Robbins and Coltran Pathologic Basis of Disease (Elsevier, 10^th edition 2020)

Coleman WB, Tsongalis GJ, Molecular Pathology: The Molecular Basis of Human Disease (Academic Press 2^nd edition, 2017)

Immunology

Murphy K M, Waver C, Berg L, Janeway’s Immunobiology (Norton and Company, 10^th edition 2022)

Abbas A K, Lichtman A H, Pillai S, Cellular and Molecular Immunology (Elsevier, 10^th edition, 2021)