MolPatho 2023

Pathology and Immunology

Module code


Abbreviated title


Module components

Lectures, seminar


Semesters 1+2 (duration of each part: 2 semesters)

Module coordinator/


 E. Hütten


Pathology: P. Rosenstiel (IKMB) 

Immunology: D. Wesch, H. Oberg, D. Adam, O. Janssen, M. Lettau, A. Scheffold (Immunology)

Contact hours

Lecture Pathology 3 CH                 Lecture Mol. Pathology 1 CH                                Seminar Pathology 1 CH                Lecture Basic immunology 2 CH     

Lecture Molecular immunology 2 CH

[Immunology also for Biochemistry + Molecular Biology/Biology MSc students]










Total: 240 h

Lecture Pathology 1st semester: 90 h
Attendance time 38 h, preparation 20 h, revision 32 h
Lecture Molecular Pathology 2nd semester: 30 h
Attendance time 14 h, preparation 6 h, revision 10 h
Seminar Molecular pathology 2nd semester: 60 h
Attendance time 14 h, preparation 24 h, revision 22 h

Lecture Introduction to immunology 1st semester: 30 h

Attendance time 26 h, revision 4 h

Lecture Introduction to molecular immunology 2nd semester: 30 h

Attendance time 26 h, revision 4 h

Credit points

8 (lecture Pathology 3 CP; lecture Mol. Pathology 1 CP, seminar 2 CP; lecture Immunology 1 CP, lecture Mol. immunology 1 CP)



Expected outcome

Knowledge: Students

- understand pathological processes of primary disease entities
- understand neoplastic and inflammatory processes and their impact on tissue
- understand the principles of molecular and cellular change in degenerative diseases of different organ systems (e.g. Alzheimer’s disease, Parkinson’s disease, prion diseases of the CNS)

- are familiar with the development, roles and interaction of cellular and humoral components of innate and adaptive immunity

- have a good understanding of the molecular basics of the development of the immune system demonstrated at model systems of various species
- are familiar with the molecular basics to differentiate between leucocyte populations (surface antigens, flow cytometry)

- have gained thorough knowledge about the molecular interactions of antigen receptor-induced activation and cytokine-induced activation, differentiation and effector function of various leucocytes populations

- understand the molecular context of selected key signal transduction pathways in cell growth and cell death

- understand normal and pathological immune responses for e.g. allergies, autoimmune diseases, infections, congenital/ acquired immune deficiencies, tumour development, prion diseases, graft rejections.

Skills: Students

- recognise macro- and microscopic pathological changes and can link them to molecular processes

- recognise, understand and can explain cellular processes such as cell differen-tiation, cell division and cell death for chosen examples.

Competences: Students

- understand pathology of malign processes as a concept and can transfer their knowledge to other topics within their studies.


Lectures and seminar Pathology, Molecular pathology: Organisation of the cell/ cell layers/organs; injury and cell death; cell organelles and specific diseases (storage diseases, mitochondrial diseases); regeneration and proliferation; basics of neoplastic diseases; inflammation and diseases of the immune system; bacterial infectious diseases, sepsis, viral infectious diseases; haemorrhage and ischaemia; senescence and age-related changes in cells; degenerative processes;  diagnostic techniques; animal models in researching human diseases.

Lecture Basic immunology: Basics of immunology, evolution of the immune system; innate and adaptive immunity; antigen presentation and dendritic cells; T-cell and their subpopulations; B-cells and antibodies; allergy, autoimmunity, immunology of infection, tumour immunology, immune deficiencies, tolerance and transplantation immunology, immunology of the skin, immunodiagnostics, tissue typing.

Lecture Molecular immunology: Receptor evolution in the innate/adaptive immune system; animal models in immunology; specificity of the immune system: T-cell and B-cell receptors; immune response regulation by cytokines and growth factors; cell growth and apoptosis; compartmentalisation of pathways; techniques in cellular and molecular immunology.

Module evaluation/



Oral exam in Pathology (2nd semester); no exam in Immunology

Media used

PPT presentations, handouts



Kumar V, Abbas AK, Aster J, Robbins and Coltran Pathologic Basis of Disease (Elsevier, 10th edition 2020)

Coleman WB, Tsongalis GJ, Molecular Pathology: The Molecular Basis of Human Disease (Academic Press 2nd edition, 2017)


Murphy K M, Waver C, Berg L, Janeway’s Immunobiology (Norton and Company, 10th edition 2022)

Abbas A K, Lichtman A H, Pillai S, Cellular and Molecular Immunology (Elsevier, 10th edition, 2021)