Oncology I

Module code

mlsOncologyI-01a

Abbreviated title

Oncology I

Module components

Lecture, seminar, practical exercise

When

Semester 2

Module coordinator/

Organiser

S. Sebens

IET

Lecturers

N. Arnold (Gynaecology), L. Lenk (Pediatrics), A. Trauzold (General and Thoracic Surgery), S. Sebens (IET), M. Peipp, T. Valerius (Med. Department II) and colleagues

Contact hours

Lecture 2 CH                 Seminar 2 CH                    Diagnostics practical 2 CH

Workload

Total: 150 h

Lecture: 30 h
Attendance time 26 h, revision 4 h
Seminar: 60 h
Attendance time 28 h, preparation 22 h, revision 10 h
Practical exercise: 60 h
Attendance time 38 h, preparation 12 h, revision 10 h

Credit points

5 (lectures 1 CP, seminar 2 CP, practical exercise 2 CP)

Requirements

MolBio passed

Expected outcome

Knowledge: Students

- are familiar with the essential pathogenesis of malignant diseases (selected disease examples)

- are able to describe the impact of gene-environment interactions on disease manifestation on a molecular level

- are familiar with the essential diagnostic and therapeutic techniques for recognising and treating tumours.

Skills: Students

- can apply suitable statistical tests and software for data evaluation.

Competences: Students

- are able to familiarize themselves with a scientific topic through literature research

- understand an English scientific publication and can discuss it critically

- can develop an oral presentation taking into account English scientific publications

- are aware of the social and ethical implications oncological research has and take them into account in their research work.

Content

Lecture: Malignant diseases in humans, pathogenesis of malignant diseases; definition and characteristics of tumours; techniques in molecular oncology; epigenetics/micro-RNA; characteristics of tumour cells; cell cycle regulation and transcription; signal transduction; apoptosis, malignant progression; viruses and cancer; oncological therapies; stem cells.

Seminar: Discussion of current scientific publications.

Practical exercise: Rotation through diagnostic labs (e.g. osteology, staining/microscopy, bacterial cell cultures) executing lab experiments under supervision.

Module evaluation/

exam

Graded

Written exam

Media used

PPT presentations, lab experiments, manuals and instructions for lab work, case studies.

Literature

Pecorino L, Molecular Biology of Cancer Mechanisms, Targets, and Therapeutics (OUP 4^th edition, 2016)

Weinberg RA, The biology of Cancer (Garland Publishing 2^nd revised edition, 2013)

Current original publications and reviews