Focus area Oncology II

Module code

mlsOncologyII-01a

Abbreviated title

Oncology II

Module components

Lab seminar, lab practical, joint seminar of all focus areas

When

Semester 3

Module coordinator/

Organiser

S. Sebens

IET

Lecturers

N. Arnold (Gynaecology), L. Lenk (Pediatrics), A. Trauzold (General and thoracic Surgery), S. Sebens (IET); M. Peipp, T. Valerius (Med. Department II); principal investigators of research groups working on research topics of focus areas (joint seminars)

Contact hours

Practical 9 CH               Lab seminar 1 CH            Joint seminar 1 CH

Workload

Total:  330 h

Lab practical: 240 h
Attendance time 100 h, preparation 60 h, revision 80 h

Lab seminar: 60 h

Attendance time 14 h, preparation 26 h, revision 20 h
Joint seminar “Current affairs”:
Attendance time 14 h, preparation 10 h, revision 6 h

Credit points

11 (practical 8 CP, lab seminar 2 CP, joint seminar 1 CP)

Requirements

Oncology I passed

Expected outcome

Knowledge: Students

- have an in-depth understanding of physiological and molecular/cell biological processes which influence malignant diseases

- understand lab techniques for oncological research described in the literature and can explain essential methods

- have in-depth knowledge of the experiments conducted during the practical.

Skills: Students

- can conduct the different steps of their lab experiments and explain them

- are able to perform quality control measures for the results obtained

- can analyse the results and put them into relation to the research area.

Competences: Students

- can plan experiments, analyse the data and interpret results gained

- can reflect their own work critically and integrate new results adequately

- can familiarize themselves with a new topic and develop research approaches

- are aware of the connections between the topics of the different focus areas, can link and explain them.

Content

Seminar: Planning and preparation of a project in the seminar by literature research and discussions with fellow students and lecturers.

Discussion of method papers: sequencing techniques, immunohistochemistry, fluorescence in –situ hybridisation; comparative genome hybridisation on arrays; blotting techniques.

Practical: Performance of experiments for a lab project on topics such as effect of oncogenes, tumour supressor genes, development of mutations; signal transduction in cells and analysis of results. Preparation of tumour cells (RNA/DNA/proteins) for their application in various lab techniques.

Joint seminar: Joint discussion of papers relevant for all focus areas.

Module evaluation/

exam

Graded

Scientific project thesis with oral presentation

Media used

PPT presentations, lab instructions, lab experiments.

Literature

Pecorino L, Molecular Biology of Cancer Mechanisms, Targets, and Therapeutics (OUP 4^th edition, 2016)

Weinberg RA, The biology of Cancer (Garland Publishing 2^nd revised edition, 2013)

Current original publications and reviews